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Health Canada has approved RYBELSUS (semaglutide tablets) to reduce major adverse cardiovascular events cardiovascular death, nonfatal myocardial infarction or nonfatal stroke in adults with type 2 diabetes who have established cardiovascular disease or are at high risk for these events

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Medical supervision is essential if both are being used

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Experiments in rat models indicated a potential reduction in reactive oxygen species buildup and associated cell damage, while cell-based studies noted improved neuronal survival under excitotoxic stressors

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