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Moderate Clinical Evidence Some supportive human research exists, but meaningful limitations remain
Contact your GP, trial team, or seek urgent medical care if you experience any of the following: Diarrhoea lasting more than seven days without improvement Blood or mucus in the stool, which may indicate colitis or another serious gastrointestinal condition Signs of dehydration, including dizziness, reduced urine output, dry mouth, or confusion particularly in older adults or those with diabetes
Additionally, the presence of publication bias suggested by Eggers test and funnel plot asymmetry indicates that smaller studies with non-significant results might be underrepresented
All animal studies were approved by the State of Bavaria, Germany, or the Insitutional Animal Care and Use Committee of the University of Cincinnati, OH, USA and conducted on the basis of the underlying animal welfare law of the respective countries
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