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They suggested sialidase can affect the concentration of sperm associated with sialic acid.26 In seminal plasma, positive correlation of pyruvate concentration with sialidase activity has been reported.26 Pyruvate can be used as a source of energy by the sperm cell in the presence of acetyl permease in seminal plasma.27 According to the results of Toit et al., 28 spermatozoal ATP concentrations showed a positive correlation with sperm-related sialic acid concentrations