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For acute injuries with significant pain, split dosing may offer advantages
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But cagrilintide won decisively on tolerability: GI adverse events 54.0% vs 73.8%, and discontinuation for adverse events 2.6% vs 3.6% (cagrilintide was actually below the 3.5% placebo rate)
This has drawn interest from researchers studying shift workers and those with circadian misalignment
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