I'd love to hear your thoughts
310 Key mechanisms supporting DTP survival include chromatin reconfiguration mediated by histone-modifying enzymes, activation of stress-response and bypass signaling pathways such as IGF-1R, AXL and YAP/TAZ, and a shift toward oxidative or alternative nutrient metabolism, often coupled with enhanced mitochondrial ETC dependency, selective mitophagy and resistance to lipid peroxidation, which together mitigate therapy-induced apoptosis
By helping patients lose significant amounts of weight safely, these medications reduce the physical and inflammatory burdens on the spine
IV administration avoids GI upset for faster systemic immune support
N Engl J Med 352, 20-28.), 3 anti-inflammatory therapy targeting the IL-1 innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering (Ridker, P