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Journal of Pharmaceutical and Biomedical Analysis, 89 , 122129
Elevated circulating IGF-1 led to an activation of the IGF-1PI3KAkt signalling pathway, causing augmented mTOR phosphorylation and higher phospho-FoxO/total FoxO ratio in skeletal muscle of LC supplemented rats [33]
10.1073/pnas.2213157119 11
While patients typically experience efficient weight loss, they might feel lethargic and fatigued while taking the medication because of GI side effects and reduced calorie intake
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