surmount-4 tirzepatide withdrawal weight regain What happens after transitioning off GLP-1 medication? In this episode of the Metabolic Balance Stories podcast, we speak with Gerry Gajadharsingh about the growing use of GLP-1 medications and the question of Do You Have to Taper

The FDA recently approved versions of GLP-1 medication - including Wegovy (semaglutide), Saxenda (liraglutide), and Zepbound (tirzepatide) - for chronic weight management

This creates a concentration of 23.33mg/mL

Side effects may begin to improve about 1 week after stopping, although the medication remains in the system longer

doi: 10.1016/s1001-9294(09)60059-6 106 RadstakeTRvan der VoortRten BrummelhuisMde Waal MalefijtMLoomanMFigdorCGet al

Another delayed effect seen with chronic administration of antipsychotic drugs is proliferation of DA receptors, detectable as an increase in haloperidol binding (Seeman 1987), and also a pharmacological supersensitivity to DA, somewhat akin to the phenomenon of denervation supersensitivity