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Through a comprehensive analysis of histone modifications in lesional skin from both psoriasis patients and mice, the significantly increased level of histone acetylation at H4 lysine 16 (H4K16ac) in macrophages was found, which was positively correlated with the accumulation of self-RNA in the dermis and psoriasis pathology
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PNAS 116 (28), 1392713936
In senescent cells, FOXO4 binds to p53 and prevents apoptosis, allowing these damaged cells to persist
The degree of liver fibrosis and the number of p53- or progerin-positive cells were quantified with Image J software
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