Baseline (before starting GLP-1 or supplements): 25-hydroxyvitamin D (target: 30-50 ng/mL) Vitamin B12 (target: above 400 pg/mL) Serum iron, ferritin, and TIBC Serum magnesium Serum zinc Complete metabolic panel CBC (to check for anemia) Follow-up testing at 3 and 6 months: Repeat all baseline labs Add: body composition measurement (DEXA scan is gold standard) to track lean mass vs fat mass changes Assess supplement adherence and adjust doses based on results The cost of basic nutritional bloodwork is minimal compared to the cost of undiagnosed deficiencies
Charles Glaus and Rick Jacobsen at Amgen Inc for their valuable input and Amgen Inc for material support of L2-Cmu
Off-label use for fatty liver disease specifically would be at the discretion of specialist hepatologists or endocrinologists, typically in research settings or exceptional clinical circumstances
Circulation 136:849870 Honigberg MC, Chang LS, McGuire DK, Plutzky J, Aroda VR, Vaduganathan M (2020) Use of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes and Cardiovascular Disease: A Review
Correct homeostasis model assessment (HOMA) evaluation uses the computer program