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Medical contraindications and usewithcaution groups Even if regulators dont ban it outright, clinicians and safetyreview papers suggest avoiding or proceeding with extreme caution if you have: Active pancreatitis or high risk of pancreatitis Preclinical work links some GLP1like pathways (relevant to BPC157 formulations) with pancreatitis risk

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The 2025 NEJM trial comparing tirzepatide directly against semaglutide showed 20.2% versus 13.7% weight loss over the same treatment period

Skin Changes: Your skin may become more vulnerable to damage from free radicals, potentially resulting in uneven skin tone and a loss of radiance

The vial is contaminated and should be discarded