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Heres what current studies show: People taking the highest dose of retatrutide (12 mg) in the latest phase 3 trial lost an average of about 24% of their body weight in about 68 weeks
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Building on this momentum, Wegovy also gained FDA approval for Metabolic Dysfunction-Associated Steatohepatitis (MASH) in 2025
Kuypers FA, de Jong K
In pre-specified analyses for time to first occurrence of MACE, there were 44 MACE-5 (all-cause death, heart attack, stroke, heart failure event, or coronary revascularization ) events observed in participants randomized to retatrutide (pooled 9 mg and 12 mg) and 52 events observed in those randomized to placebo, resulting in a hazard ratio of 0.82 (95.0% CI: 0.55 to 1.22)
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