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Unlike traditional small molecule inhibitors, PROTACs do not require continuous blocking of protein activity, but instead induce target protein degradation [106], By fundamentally reducing their numbers, this unique mechanism offers the possibility of targeted intervention for undruggable proteins
Manufacturers must carefully balance regulatory risk with commercial opportunity, making strategic planning essential for sustainable market participation
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However, we wanted to compare the array method to more conventional methods of identifying glutathionylated proteins using BioGEE, for example, by mass spectrometry following affinity purification on streptavidin beads 17,25
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