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Despite most prokaryotes and animals possess enzymes that require B12 as cofactor, only some bacteria and archaea are able to synthesize B12 de novo 3

Furthermore, the lack of regulation means that there is no guarantee that you will receive a genuine and safe product that is free of dangerous substances

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In this case, if high folate intake continues to hide the symptoms of B12 deficiency for a long time, a slow but irreversible damage to the brain and nervous system may occur