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While these approaches have garnered important information about the pathways regulating some of the cellular responses leading to PCO, established lens epithelial cell lines have a profoundly different transcriptome than bona fide LECs residing within the mammalian lens, and often have dysregulated cell cycles resulting from either transformation with SV40 or just selection for growth in culture (162166)

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Ice crystals that form during freezing physically shear peptide bonds, similar to the damage caused by vigorous shaking

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