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Avoid starting new patients on GLP-1 treatment until supply stabilizes

While some preclinical research has explored potential immunomodulatory effects of GLP-1 receptor agonists, there is currently insufficient clinical evidence to establish this as a mechanism for systemic symptoms in patients taking tirzepatide

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Notably though, the accompanying treatment algorithms do not explicitly recommend combination therapy

Precautions and not-recommended situations include history of pancreatitis, severe gastroparesis or other serious gastrointestinal disease, pregnancy/lactation (discontinue before conception), and type 1 diabetes