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IC 50 = 32.5 M) (Table 1 and Supplementary Table 20)

With that caveat, here is what the published Phase 3 data say at peak dose, in adults with obesity and without diabetes: The roughly 6-percentage-point gap between retatrutide and tirzepatide at peak dose, sustained across more than 2,000 participants, is the data point payers and prescribers will spend the next year arguing about

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They do this by mimicking glucagon-like peptide-1 (GLP-1), a hormone made naturally in the human gut