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Despite these promising findings, most gastroenterologists acknowledge that GLP-1 medications are not yet standard-of-care treatments for IBS, and patients should discuss potential benefits and risks with their healthcare providers before starting therapy

doi:10.1038/273120a0

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Pattern 2: The Non-Responder (approximately 15% of switchers) Weight loss plateaus or slows despite escalating to Zepbound 12.5 to 15 mg May report initial response at 5 to 7.5 mg that fades by week 16 to 20 Often have underlying metabolic factors (severe insulin resistance, hypothyroidism, medications causing weight gain) For this group, the switch to tirzepatide does not solve the core problem