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Thats also the benchmark we used to identify the best options included here

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12 and over for adolescent obesity through a specialist service No contraindications (reasons not to prescribe the medication) listed in the Wegovy Summary of Product Characteristics Commitment to lifestyle changes alongside the medication The contraindications listed in the Wegovy SmPC include: 4 Pregnancy, breastfeeding, or trying to conceive Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 History of pancreatitis Severe gastrointestinal disease, including gastroparesis Severe kidney problems (eGFR less than 30 ml/min/1.73m) Type 1 diabetes or a history of diabetic ketoacidosis The prescription process for most providers starts with an online health questionnaire reviewed by a GMC-registered prescriber, followed by an ID check to comply with MHRA regulations

Furthermore, it is the only therapeutic that accompanies significant loss of fat with significant gain of lean mass

J Immunol 199:7281