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Vitamin C Sources Vitamin C and glutathione have a unique relationship

Importantly, each hallmark was defined not only by its association with aging, but also by experimental evidence suggesting that modifying these mechanisms could influence lifespan or healthspan

doi: 10.1007/s00125-008-1149-y 133 GromadaJFranklinIWollheimCB

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The millimolar GSH intracellular concentrations, the low plasma micromolar concentrations and the low GSH redox potential ( E 0 = 240 mV) make GSH an ideal and perfect cellular redox buffer (Figure 2) ( FIGURE 1 FIGURE 2 Glutathione is synthesized in the cytosol of all cells from their precursor amino acids: glutamic acid, cysteine and glycine by consecutive action of two enzymes: -glutamyl-cysteine (-GluCys) synthetase (also known as glutamate cysteine ligase, GCL) that in a first step uses glutamate and cysteine as a substrate to form the dipeptide -glutamyl-cysteine