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Additionally, it improves liver enzyme levels, reduces steatosis and stiffness, and thereby reduces the risk of liver fibrosis

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

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To further confirm the involvement of Nrf2, Nrf2 expression was down-regulated by Nrf2 siRNA transfection, which significantly increased the expression of inflammatory factors including IL-6, iNOS, as well as the cartilage matrix degradation factor, MMP13, in chondrocytes treated with metformin

Published in the New England Journal of Medicine, this trial enrolled 2,539 adults with obesity or overweight (with at least one weight-related comorbidity) who did not have diabetes