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5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), not a peptide
NAD+ is an essential cofactor for sirtuins (SIRT1-7), DNA repair, and mitochondrial function
ROS can be regulated by glutathione peroxidases (GPxs), which are the key enzymes that maintain ROS homeostasis in vivo through the reduction of ROS [10]
Numerous gastrointestinal conditions, such as irritable bowel syndrome, inflammatory bowel disease, and small intestinal bacterial overgrowth, have been associated with dysbiosis (an imbalance or disruption in the composition and diversity of the gut microbiome) [111]
Cell 24 , 17761790 (2013)
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