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312 Similarly, EMT contributes to oxaliplatin and cisplatin resistance in gastric and colorectal cancers, mediated by factors such as Rab31 (via the Stat3/MUC-1/Twist1 axis) and THBS2 CAFs (via COL8A1-driven PI3K/AKT signaling)
For instance, a number of ongoing or completed trials are evaluating inhibitors of the PI3K-AKT-mTOR cascade, such as gedatolisib (NCT03065062) in advanced solid tumors, capivasertib (NCT04305496) in hormone receptor-positive breast cancer, and alpelisib (NCT02437318), which has shown efficacy in advanced breast cancer and is already approved for PIK3CA-mutated cases
Nutrients 15(12)
The pineal gland, from which Epithalon was originally derived, governs melatonin production and circadian rhythm
