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Therefore,

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Receptor internalization and beta-arrestin recruitment occur with each agonist exposure regardless of dose magnitude varying dose between administrations changes peak receptor occupancy but does not reset downregulation kinetics

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P = 0.41), while male interim survival with L2-Cmu was indistinguishable from Controls (Supplementary Fig

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The Bottom Line Recruitment is expected to take place over an extended period, followed by months of treatment and safety monitoring for each participant

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