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Alternatively, GLP-1 RA might directly act on renin-producing cells within the juxtaglomerular apparatus, where GLP-1 receptors have been identified or might directly protect podocytes from apoptosis [58,59,60]
Summary In conclusion, the decision to transition from semaglutide to tirzepatide is multifaceted, hinging on factors such as efficacy, safety, individual health needs, and financial considerations
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