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The included peptides are individually studied in in-vitro cell culture models for effects on inflammatory cytokine modulation, NF-B pathway signaling, and immune cell function assays

Ugawa T, Kakuta H, Moritani H, Matsuda K, Ishihara T, Yamaguchi M et al (2000) YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species

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alterations in ketone body and amino acid/protein metabolism have been described in patients affected by HF, as well as mitochondrial dysfunction and other modified metabolic signaling