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In the presence of T3, TRs interact with coactivators like TRAP (thyroid receptor-associated protein), which increases gene transcription
These compounds are widely referenced in preclinical literature because they act on pathways directly tied to muscle protein turnover, rather than through indirect or unverified mechanisms
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Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder
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