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This poster presents key challenges encountered during method development and validation, and discusses the strategies implemented to overcome them

This review systematically describes the multi-target mechanisms of SIRT1 in MASLD pathogenesis through its regulation of critical factors, including peroxisome proliferator-activated receptor gamma coactivator 1-, Forkhead Box O, and nuclear factor kappa-light-chain-enhancer of activated B cells, which govern hepatocyte lipid remodeling, mitochondrial quality control, autophagyendoplasmic reticulum stress balance, and Kupffer cell/T cell polarization

Dehydration amplifies nausea sensation and can worsen dizziness

Higher doses increase this signaling effect, but they also elevate the risk of side effects like nausea and vomiting

The question of whether these two therapies can safely work together requires a clear understanding of how each one functions and what clinical evidence shows about their combination