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Transcellular passage is also minimal, as peptides exceed Lipinskis Rule of Five (Ro5) limits and carry many hydrogen-bond donors/acceptors, both of which further contribute to extremely low oral bioavailability
Miralax typically takes one to three days to produce a bowel movement, so it is best used as a daily preventative rather than a "rescue" medication
The goal is to keep the dose right for ongoing weight loss while staying safe and tolerable
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