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Goldberg AD, Becker LC, Bonsall R, Cohen JD, Ketterer MW, Kaufman PG,
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Thereafter, mice were divided into two groups ( n = 6/group) and started on one of two treatments: a control diet (Con) and HFD
IGF-1 is a highly anabolic peptide hormone responsible for: Muscle cell proliferation and repair Tendon and ligament regeneration Bone growth Glucose uptake in muscle cells Increased satellite cell activation Oral administration of MK-677 raised serum IGF-1 levels by over 60% in healthy adults without altering cortisol, insulin, or gonadotropin concentrations. Chapman et al., Clinical Pharmacology & Therapeutics This rise in IGF-1 is what leads to muscle growth, improved recovery, and increased physical resilience over time
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