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Being able to walk further, sleep on the affected side, or perform previously painful movements represents meaningful progress beyond simple pain relief

A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment

Skin irritation, redness, and temporary dryness at the application site are the most commonly mentioned issues

Overall, while lactylation represents an intriguing link between metabolism and epigenetic regulation, the current understanding remains preliminary

Additional information Peer review information Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work