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In addition, in sorting rounds 4 and 5 of the second pathway, two reactions were performed in parallel: labeling in the absence or presence of low-concentration quenchers to prevent transcellular labeling
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[48] A 2024 systematic review of 6 studies found that while lean body mass was unchanged in some cases, there were instances of significant decreases in lean body mass (040%)
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Over the next years, it will be important to understand the effect of the reduced circulating amino-acids with the novel multi-agonists targeting the glucagon receptor on lean muscle mass (especially in populations with obesity and high risk of sarcopenia) as well as on energy expenditure [66]
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