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What's on the horizon with GLP-1s
A causal link between free fatty acid and endothelial dysfunction has been established by multiple pathways 16,17,18,19
The link between oxidation and inflammation is complex, going from fine-tuned signaling by ROS during TLR4 activation that leads to active mobilization of damaged-associated molecular patterns, to cellular injury from redox stress that leads to damaged-associated molecular patterns release triggering TLR4-mediated inflammation and organ injury (Gill et al., 2010
Weight loss was also observed, with a modest correlation between alcohol reduction and weight change, suggesting GLP-1RAs may simultaneously target both alcohol use and obesity
Vitamin B12 helps to keep up proper neurological functioning, and its deficiency can lead to neuropathy
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