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Semaglutide and MASH resolution: A pooled analysis of recent trials [PMID: 40726455] Laboratory literature summary: Semaglutide and MASH resolution: A pooled analysis of recent trials

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This disrupts calcium homeostasis and initiates a severe hypermetabolic response (Stephens et al., 2016

Based on the linear regression slopes (Table 2), each 10% reduction in body weight with semaglutide was associated with a 6.4-point (95% confidence interval (CI): 4.1, 8.8) increase in KCCQ-CSS, a 14.4-m (95% CI: 5.5, 23.3) increase in 6MWD and a 28% (95% CI: 16, 37) decrease in CRP, after adjusting for baseline age, sex, body weight, endpoint value, NYHA class, coronary artery disease, atrial fibrillation, CRP (log-transformed) and NTproBNP (log-transformed)

They had low blood pressure on my examination