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The Asia-Pacific region, tropical Latin America, and North America each have relatively low prevalence rates, under 1.5%
Electrolyte imbalances from reduced food consumption may also contribute to headache frequency
Key nutrients to prioritize: Protein to protect muscle mass Fiber (2530 g/day for women) to support fullness and prevent constipation Hydration Micronutrients such as calcium, iron, and vitamin D Hormonal shifts can further influence digestion and metabolism, particularly in women navigating overlapping conditions such as PCOS and perimenopause, explored in The PCOSPerimenopause Connection
Delphinidin 3-rutinoside (D3R) through GPR40/120 and the Ca 2+ -calmodulin-stimulated protein kinase II (CaMKII) pathway activation stimulates GLP-1 secretion [189]
It helps neutralize free radicalsunstable molecules that can damage cells, proteins, and DNA
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