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While the latter might be relevant to conditions such as pathogen challenge, current concepts suggest that the relatively low antioxidant complement of the apoplast enables this compartment to exist in a more oxidized state compared to the cell interior (Pignocchi et al
Cadinu D, Grayson B, Podda G, Harte MK, Doostdar N, Neill JC
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Available at: fda.gov/fdac/features/1998/498_pd.html
The Itga8-Cre/Itga8-CreERT2 model avoids myeloid cell leakage and does not induce the lethal visceral myopathy commonly seen in Myh11-driven models, making it an ideal tool for studying VSMC sex differences and remodeling processes [238, 239]
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