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2 Overview of osteoarthritis and ferroptosis 2.1 Pathogenic mechanisms of osteoarthritis OA is a common degenerative joint disease marked by gradual cartilage degradation, destruction of subchondral bone structure, synovial inflammation, and clinical symptoms such as joint pain
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According to previous research, cardiovascular pathophysiology includes cell death, inhibition of DNA/RNA/protein synthesis, increased production of reactive oxygen species (ROS), impaired energy metabolism, mitochondrial dysfunction, interstitial fibrosis, autophagy disorders and disorders of intracellular calcium homeostasis (Kong et al
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