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Clinically meaningful weight loss is generally defined as 5% reduction from baseline, with many patients achieving 10-15% or greater reduction over 6-12 months
Furthermore, in a gentamicin (GM)-induced nephrotoxicity model, curcumin activated the Nrf2/PGC-1 signaling pathway, preserving mitochondrial integrity and energy metabolism (Negrette-Guzmn et al., 2015)
Normal adjustment produces temporary, manageable symptoms that improve with continued use rather than escalating into allergic response
Summary Keywords interstitial cystitis, phytochemicals, uroprotective, inflammation, inflamed bladder tissue, painful bladder syndrome Citation Anjum I, Nasir A, Naseer F, Ibrahim A, Rehman B, Bashir F and Tul Ain Q (2025) Exploring the anti-inflammatory effects of phytochemicals in attenuating interstitial cystitis-a literature review