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GLP-1 drugs (exenatide, liraglutide etc), as well as GIP/GLP-1 hybrid peptides (tirzepatide), are clinically approved for diabetes and/or obesity, with GLP-2 based drugs (teduglutide) approved for the treatment of short bowel syndrome

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Individuals with a history of gastrointestinal issues, such as GERD, may be more susceptible to experiencing heartburn with semaglutide

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