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There are two types of prescription only vitamin B12 medicines that are listed in the British National Formulary (BNF) by NICE (National Institute for Health and Care Excellence) to be used for treating vitamin B12 deficiencies hydroxocobalamin and cyanocobalamin

[1] Niacinamide in high doses can sometimes cause nausea, heartburn, or a sensation of warmth

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It activates AMPK signaling (the same pathway activated by exercise and caloric restriction), improves insulin sensitivity, enhances glucose uptake by muscle tissue, and supports mitochondrial biogenesis