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Contraindications/Precautions: Use with caution in patients with moderate to severely impaired hepatic or renal function

8 , eabn1229 (2022)

Thus unlike the cytosolic labile iron pool where the redox state of iron is buffered in the iron(II) state by glutathione, in aerobic cells cytosolic heme will be rapidly converted to hematin in the presence of physiological levels of glutathione