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Nat Rev Immunol 2:699706 HNER A (2001) Polycyclic aromatic hydrocarbon (PAH) metabolites
ROS are the main molecules involved in the role and mechanism of GPxs in the development of diseases ROS, reactive oxygen-containing molecules, are the normal products of aerobic reactions in humans, such as oxidative respiration in mitochondria [24]
For instance, the patent CN117069743A (filed on May 10, 2022, and published on November 17, 2023) by Beijing Shenogen Pharma Group Ltd
The pathophysiology of DDES is complex, involving lacrimal gland mitochondrial dysfunction, neuro-inflammation, ocular surface dysbiosis, and meibomian gland dropout [122,123,124]
Women with hormonal drivers (especially around perimenopause and menopause) should also get a hormone evaluation, since addressing underlying hormonal shifts is often part of an effective protocol
