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High levels of intracellular L-arginine have been shown to reprogram the metabolism in activated T cells from glycolysis to oxidative phosphorylation, promoting the production of central memory-like T cells with anti-tumor activity and increasing the survival of T cells (Geiger et al., 2016)

Additional antioxidant pathways, including the GTP cyclohydrolase 1 (GCH-1)-tetrahydrobiopterin (BH4) pathway and the ferroptosis suppressor protein 1 (FSP1)-ubiquinone (CoQ)-NADPH pathway, also play vital roles in ferroptosis regulation

However, this often leads to digestive upset and wasted resources

Rouhier, N., Gelhaye, E