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The distinction matters because AOD-9604 preserves lean mass in animal models, and the mechanism of action suggests it does the same in humans
Int J Obesity 27:1359-1364, 2003
NICE does not currently have guidance on either AOD 9604 or retatrutide, reflecting their unlicensed and investigational status within the UK healthcare system
Diabetes 68(6):11211129 Grespan E, Giorgino T, Natali A, Ferrannini E, Mari A (2021) Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes
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