Older adults considering GLP-1 medications or medical weight loss should be monitored carefully and should prioritize strength, mobility, protein intake, and functional health not just scale weight
Two medications at the forefront of this evolution are tirzepatide and retatrutide

Amputation A diagnosis with ICD-10-CM code Z89.2*, Z89.6*, S78.011A, S98.011A, S78.012A, S98.012A, S78.019A, S98.019A, S78.021A, S98.021A, S78.022A, S98.022A, S78.029A, S98.029A, S78.111A, S98.111A, S78.112A, S98.112A, S78.119A, S98.119A, S78.121A, S98.121A, S78.122A, S98.122A, S78.129A, S98.129A, S78.911A, S98.131A, S78.912A, S98.132A, S78.919A, S98.139A, S78.921A, S98.141A, S78.922A, S98.142A, S78.929A, S98.149A, S88.011A, S98.211A, S88.012A, S98.212A, S88.019A, S98.219A, S88.021A, S98.221A, S88.022A, S98.222A, S88.029A, S98.229A, S88.111A, S98.311A, S88.112A, S98.312A, S88.119A, S98.319A, S88.121A, S98.321A, S88.122A, S98.322A, S88.129A, S98.329A, S88.911A, S98.911A, S88.912A, S98.912A, S88.919A, S98.919A, S88.921A, S98.921A, S88.922A, S98.922A, S88.929A, S98.929A or a procedure with ICD-10-PCS code 0Y6[23478CDFGHJ]* or 0X6[012389BCDF]* Pregnancy A diagnosis with ICD-10-CM code O*, a pregnancy episode, or a birth record Bariatric surgery A procedure with CPT code 43644, 43645, 43659, 43770, 43771, 43772, 43773, 43774, 43775, 43845, 43846, 43847, 43848, 43886, 43887, 43888, 43842, or 43843 Limitations We allow a patient to be included in each month, using their highest weight in that month

Intermenstrual or postcoital bleeding: Bleeding between periods or after sexual intercourse always requires investigation to exclude cervical pathology or other gynaecological conditions
The findings suggest that GLP-1 pathways may directly influence how some cancers grow or spread, though researchers say more studies are needed to understand the mechanism behind this effect