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Ongoing and future largescale randomized trials will be critical for clarifying efficacy and safety for this use

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Diagnostic workup was notable for thiamine deficiency, NCS/EMG showing a severe, axonal polyneuropathy, and nerve biopsy redemonstrating severe axonal neuropathy

For example, paying attention to the pivotal role of oxidative pressure in the pathogenesis of periodontitis, further research can focus on how antioxidants decrease the production of reactive oxygen species or boost the bodys antioxidant defense systems to promote the inflammatory status and fix capacity of periodontal tissues

Standard human dosing protocols based on animal studies suggest 0.25-0.5 mg daily via subcutaneous injection for 4-8 weeks