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A recent clinical trial shows that it is effective as an adjunctive treatment along with immunomodulatory medications for treatment-resistant major depressive disorder.[ref] Minocycline has also been shown in animal studies to work on anxiety.[ref] A 2021 study showed that adding minocycline to antidepressant treatment in people with elevated C-reactive protein significantly reduced depression levels

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If a patient receives a dosage significantly higher than advised, serious side effects like renal failure or blood poisoning may manifest