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This is the first RCT of repeated ketamine dosing in patients with TRD, in which two- and three-times weekly treatment schedules over up to 4 weeks showed comparable efficacy that was superior to placebo

SLNs exhibited sustained drug release and high permeability, further enhancing drug utilization when formulated within SLNs

The terms "loading" and "maintenance" are practitioner-coined

16 Janeways hypothesis gained substantial support in 1996 through research by Hoffmann, Bruno Lemaitre, and their team

These findings suggest that cell pro-inflammatory factors such as IL-1, IL-6, and TNF- are key immunological hubs through which the oral cavity microbiota affects intestinal homeostasis and drives systemic inflammation and disease progression