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465 The anterior cingulate cortex, essential for emotional pain processing, shows increased blood flow in patients with PDPN, a hyperperfusion state that normalizes following duloxetine treatment

Excessive alcohol, bile acid imbalances, hormonal fluctuations, and aging-related changes additional factors that erode barrier integrity over time

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Here, an intestinal enzyme known as -glutamyltransferase rapidly hydrolyzes (breaks down) the tripeptide structure of glutathione into its constituent amino acids before it can be absorbed intact