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It is known that individuals with an anatomical predisposition (disc at risk), whether or not they are taking a GLP-1 agonist, are at highest risk of developing NAION, the updated PI now reads
Thyroid tumor risk: People with a history of MTC or MEN 2 are excluded from current trials, suggesting similar precautions are likely if retatrutide is approved
Shahreyar M, Fahhoum R, Akinseye O, Bhandari S, Dang G, Khouzam RN
Distribution and metabolism of delta sleep-inducing peptide in mouse brain
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