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PF-06882961 was a partial agonist in recruiting Arr2 (EC 50 = 490 nM, E max = 36%), while exenatide (Arr2 EC 50 = 9.0 nM, E max = 75%) and liraglutide (Arr2 EC 50 = 20 nM, E max = 99%) were respectively 54- and 23-fold more potent with greater E max values
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these findings suggest that tumor regression in response to chemotherapy was correlated with the inhibition of GPx1 activity and confirmed the role of GPx1 in the occurrence and development of breast cancer (Fig
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